The short version of REV-ERB fits in a sentence. The long version — which is the one that helps — is below.
This page was last updated on 2025-09-05 and is reviewed periodically as new material appears.
Laboratory identification of SR9009 typically relies on chromatographic separation coupled to mass spectrometry, often with ultraviolet detection as a secondary check. Nuclear magnetic resonance spectroscopy can confirm molecular structure when a reference standard is available. Because many suppliers sell the compound as a research chemical, independent identity testing is important for experimental reproducibility. A single retention time is not sufficient proof of identity, especially when related compounds may be present. Purity assessments usually report a percentage based on area normalization.
SR9009 is generally described as poorly soluble in water and more soluble in organic solvents such as dimethyl sulfoxide and ethanol. Stock solutions are commonly prepared in an organic solvent before dilution into an aqueous buffer or vehicle. Precipitation can occur if the organic fraction is reduced too quickly or if the final concentration exceeds the compound's solubility limit. Sonication or gentle warming may aid dissolution in some protocols, but excessive heat can promote degradation. Container material and pH can also influence observed solubility.
SR9009 is supplied as a solid research chemical, often in milligram quantities. Laboratories typically weigh it in a controlled environment because fine powders can disperse. Stock solutions are commonly prepared in dimethyl sulfoxide and stored in small aliquots to reduce freeze-thaw cycles. Personal protective equipment and chemical fume hoods are standard when handling unknown or potent compounds. These practices address laboratory safety rather than human use.
Identity and purity of SR9009 samples are usually checked with chromatographic and spectrometric methods. High-performance liquid chromatography can separate the compound from related impurities, while mass spectrometry provides molecular mass confirmation. Nuclear magnetic resonance spectroscopy may be used for structural verification in research settings. No single method proves biological activity, and certificates of analysis should be reviewed alongside raw data. Independent testing is often needed because online products vary widely.
| Property | Value | Notes |
|---|---|---|
| Appearance | White to off-white powder | Visual inspection is not sufficient for identity. |
| Solubility | Soluble in DMSO and ethanol | Low solubility in water; stock solutions use organic solvent. |
| Storage | -20°C, desiccated, protected from light | Limits hydrolysis and photodegradation. |
| Analytical method | HPLC-UV/MS | Used for identity and purity assessment. |
| Synonyms | SR9009, Stenabolic | Naming varies by supplier. |
REV-ERB proteins typically suppress gene expression by recruiting corepressor complexes to DNA response elements. SR9009 binds these receptors and strengthens that repressive action in cell-based assays. Studies in rodents have reported changes in lipid handling, mitochondrial function, and exercise capacity after treatment. Such findings are often cited as evidence for metabolic effects, but species differences and limited pharmacokinetic data make direct translation to humans uncertain. Researchers continue to examine which effects are robust and which depend on specific experimental conditions.
SR9009 is frequently discussed alongside other REV-ERB ligands, including synthetic agonists and natural heme-related molecules. Its selectivity for REV-ERB over related nuclear receptors has been measured in binding and reporter assays, though off-target activity at higher concentrations is possible. The compound is prohibited in sport by the World Anti-Doping Agency, and it is not approved for any medical use in major jurisdictions. Products sold online may be labeled as research chemicals, and their identity and purity are not guaranteed by regulatory review.
The mechanism of action involves binding to REV-ERB receptors and recruiting corepressor complexes, which represses target gene transcription. This contrasts with many nuclear receptor agonists that activate transcription. Downstream effects may include changes in autophagy, mitochondrial biogenesis, and lipid handling, but the precise pathways remain an active area of study. Whether these molecular events translate into meaningful physiological effects in humans is unresolved. Most evidence comes from cultured cells and rodent models rather than human participants.
SR9009 is a synthetic small molecule developed as an agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2). These receptors help regulate circadian rhythms and metabolic gene expression. In cell and animal studies, SR9009 alters transcription of genes involved in lipid metabolism, inflammation, and mitochondrial function. It is not an approved medicine, and its pharmacological profile in humans remains largely uncharacterized. The compound is frequently discussed in the context of circadian biology and metabolic research rather than clinical use.
Preclinical reports have linked SR9009 to improved endurance and altered energy expenditure in rodents. Such findings have prompted interest in whether REV-ERB activation can influence skeletal muscle metabolism. However, the reported effects depend on dose, route, and experimental model, and replication across laboratories is limited. Human trials have not established comparable outcomes, so claims about exercise performance remain speculative. The absence of controlled human data is a central limitation in interpreting these observations.
== Awards and honours == 2020 Preis der Stadt Wien für Naturwissenschaften 2017 European Research Council (ERC) Advanced Grant 2015 Honorary member of the Swiss Society for Allergology and Immunology 2010 Virchow Medal, Medical Faculty, University of Würzburg 2012 European Research Council (ERC) Advanced Grant 2009 Full member of the Austrian Academy of Sciences 2005 Corresponding member of the Austrian Academy of Sciences 2001 Wittgenstein Award 2000 Member of the Academia Europaea 1990 Member of the European Molecular Biology Organization (EMBO) 1981 Postdoctoral fellowship (Swiss National Science Foundation)
Xylazine is a potent α2-adrenergic receptor agonist. When xylazine and other α2-adrenergic receptor agonists are administered, they distribute throughout the body within 30 to 40 minutes. Due to xylazine's highly lipophilic nature, it directly stimulates central α2-adrenergic receptors as well as peripheral α-adrenergic receptors in a variety of tissues. As an agonist, xylazine reduces release of norepinephrine in the central nervous system. It does so by mimicking norepinephrine in binding to the pre-synaptic surface autoreceptors, which leads to feedback inhibition of norepinephrine release. Recent data suggests that xylazine treatment can induce dopamine release in the nucleus accumbens through an unresolved mechanism, and this effect is blocked by atipamezole. Xylazine also serves as a transport inhibitor by suppressing norepinephrine transport function through competitive inhibition of substrate transport. Accordingly, xylazine significantly increases Km and does not affect Vmax. This likely occurs by direct interaction on an area that overlaps with the antidepressant binding site. For example, xylazine and clonidine suppress uptake of iobenguane (MIBG), a norepinephrine analogue, in neuroblastoma cells. Xylazine's chemical structure closely resembles clonidine. It has also been reported that xylazine activates the κ-opioid receptors, with low potency, which may contribute to its effects. Unlike other α2-adrenergic receptor agonists xylazine does not have any imidazoline receptor activity.
Co-Founder and Co-Chair, Chinese Welfare Trust and Trustee, Islington Chinese Association. For services to the Chinese Community in London. Philip Richard Chandler. For services to the community in Herefordshire. Patrick Chapman. For services to the Creative Industries and to Higher Education. Robert Christie. Head Coach, Scotland Paralympic Lawn Bowls Team. For services to Lawn Bowls. Michael Cladingbowl. For services to Education. David McCrorie Shearer Clark. School Support Officer, Aberdeenshire Council. For services to Education. Emilia Isobel Euphemia Rose Clarke. Co-Founder and Trustee, SameYou. For services to People with Brain Injuries. Jennifer Susan Dodd Clarke. Co-Founder and Chief Executive Officer, SameYou. For services to People with Brain Injuries. Gillian Petrina Clayton. Intelligence Led Programme Manager, Environment Agency. For services to Environmental Crime, Enforcement and Intelligence. William Cleere. Committee Member, Berkshire and Buckinghamshire Referees Association. For services to the community in Buckinghamshire. David Clifford. Fundraiser, Macmillan Cancer Support. For services to Charitable Fundraising in Clackmannanshire. David Lampton Grey Cochrane. Head of Forensic Social Work, Forensic Mental Health and High Secure Care, West London NHS Trust. For services to Health and Social Care. Joan Lorna Jeannette Cocking. Chair of Governors, Kent College Canterbury. For services to Education. Justin Anthony Cohen. News Editor, Jewish News. For services to Holocaust Remembrance and to the Jewish Community. Robert George Coles.
Sources: en.wikipedia.org
== Prognosis == In open-angle glaucoma, the typical progression from normal vision to complete blindness takes about 25 years to 70 years without treatment, depending on the method of estimation used.
=== Non-Levantine groups claiming Israelite ancestry === Largely owing to the spread of Christianity and Islam globally, several groups of people outside of the Levant have claimed Israelite ancestry on an ethnic or racial basis. These various non-Levantine groups include Mandaeans, Pashtuns, British Israelists, Black Hebrew Israelites, Igbos, Mormons, and the Christian Identity movement. The phenomenon became especially prevalent after the founding of the State of Israel in 1948, as the country's Law of Return grants citizenship to qualified Jews and to non-Jews who are either married to a Jew or provide sufficient evidence of having Jewish ancestry.
=== Clean energy roll-back === The bill was described by The New York Times as derailing renewable energy production and research in the United States, and possibly ceding the clean energy race to China. Its policies favor fossil fuel companies over renewable energy such as solar, wind, and EV manufacturing, and are expected to lead to large clean energy job losses, factory closures, and deter investment in clean technologies. Specifically, the law phases out most clean-energy tax incentives introduced under the Biden-era Inflation Reduction Act such as credits for low-carbon electricity (wind, solar), electric vehicle rebates, home electrification, clean hydrogen, and domestic manufacturing of batteries and solar panels. The law rescinds various IRA funds for grants related to freeway removal improving biking and walking in poorer neighborhoods, electric truck and bus manufacturing, faster state and local environmental reviews and place-based green industrial policy and home electrification. An April 2026 study projected the IRA's impact on clean energy investments would be nearly wiped out by the OBBBA, and emissions would be reduced by only 34 percent below 2005 levels, compared to 44 percent with the IRA. A report released by environmental group BlueGreen Alliance found that the OBBBA caused 223 manufacturing and clean energy projects to stall or be cancelled, affecting over 111,000 jobs and $82.9 billion in investment.
A number of Singaporean writers such as Tan Swie Hian and Kuo Pao Kun have contributed work in more than one language. Singapore has a diverse music culture that ranges from pop and rock, to folk and classical. Western classical music plays a significant role in the cultural life in Singapore, with the Singapore Symphony Orchestra (SSO) instituted in 1979. Other notable western orchestras in Singapore include Singapore National Youth Orchestra and the community-based Braddell Heights Symphony Orchestra. Many orchestras and ensembles are also found in secondary schools and junior colleges. Various communities have their own distinct ethnic musical traditions: Chinese, Malays, Indians, and Eurasians. With their traditional forms of music and various modern musical styles, the fusion of different forms account for the musical diversity in the country. The nation's lively urban musical scene has made it a centre for international performances and festivals in the region. Some of Singapore's best known pop singers include Stefanie Sun, JJ Lin, Liang Wern Fook, Taufik Batisah and Dick Lee, who is famous for composing National Day theme songs, including Home.
Sources: en.wikipedia.org
The researchers found no difference in post-workout plasma creatine kinase levels and muscle soreness, nor in cycling time to exhaustion. However, since chocolate milk is usually less expensive than commercial recovery beverages, the researchers concluded that chocolate milk "serves as a more convenient, cheaper ... recovery beverage option for many athletes". A May 2010 sports nutrition study concluded that "exercise recovery during short-term periods of heavy soccer training appears to be similar when isocaloric CM (Chocolate Milk) and CHO (Carbohydrate) beverages are consumed post-exercise". Yet another study in 2011 at Kean University in New Jersey concluded similar results in male soccer players, discovering that there was an increase in time to fatigue when chocolate milk was consumed. The Kean University study also viewed chocolate milk's effects on female soccer players undergoing morning and afternoon practices during preseason. They were either given the carbohydrate-electrolyte beverage or chocolate milk between morning and afternoon preseason practices. Following every afternoon practice, each athlete completed a shuttle run to fatigue. The study concluded that chocolate milk is just as beneficial as the carbohydrate-electrolyte beverage in promoting recovery in women.
Warning of the joint threats of starvation and disease, a UNICEF spokesperson stated in February 2024: "The Gaza Strip is poised to witness an explosion in preventable child deaths which would compound the already unbearable level of child deaths in Gaza". In May 2025, nine of Alaa al-Najjar's ten children, a paediatric specialist working at Nasser Hospital, were killed by an Israeli airstrike at their home in Khan Yunis, the eldest of the children aged 13 and the youngest aged six months. Her husband and tenth child were also injured from the attack, and her husband Hamdi later succumbed to his injuries.
== Diagnosis == This disorder can be suspected by symptoms, although diagnosis can be confirmed by a genetic testing. Also, diagnosis is usually made after first episode of life-threatening symptoms (such as arrhythmia).
=== Primary sequence === C3orf62 human protein (Q6ZUJ4) is 267 amino acids long, and has a molecular mass of 30,194 daltons. The isoelectric point of C3orf62 is roughly 5.2. The unmodified C3orf62 protein is a “glycine depleted protein” relative to amounts of glycine in proteins in the rest of the genome. It appears that glycine is evenly distributed throughout the C3orf62 sequence with no preference of areas to cluster in. Before post-translational modifications, C3orf62 is an acidic protein. No charge clusters are present in C3orf62, and no specific spacing of cysteine is found. The isoelectric point of C3orf62 is 5.211000.
Two additional amino acids are in some species coded for by codons that are usually interpreted as stop codons: In addition to the specific amino acid codes, placeholders are used in cases where chemical or crystallographic analysis of a peptide or protein cannot conclusively determine the identity of a residue. They are also used to summarize conserved protein sequence motifs. The use of single letters to indicate sets of similar residues is similar to the use of abbreviation codes for degenerate bases.
Sources: en.wikipedia.org
Liquid chromatography with mass spectrometry is a common approach. Ultraviolet detection and nuclear magnetic resonance can support identification when suitable standards are available.
The solid is generally kept cold, dry, and protected from light. Solutions are often frozen in single-use aliquots to reduce repeated freeze-thaw cycles.
It indicates a material sold for laboratory study, not for human use. The label does not guarantee pharmaceutical purity, sterility, or regulatory approval.
Laboratories commonly use liquid chromatography coupled with mass spectrometry to detect SR9009. The method can identify the compound and estimate concentration in a sample. Detection limits depend on the matrix and instrument.